File:Serpin mechanism.png
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Summary
| ᏄᏍᏛ ᏗᎧᏃᏗ |
English: Serine proteases operate by a two-step catalytic mechanism. First, the substrate (blue) is attacked by the catalytic triad (red) to form an acyl-enzyme intermediate. The intermediate is typically resolved by hydrolysis by water. However, when the reactive centre loop (RCL) of a serpin is attacked, the conformational change (blue arrow) pulls the catalytic triad out of position, preventing it from completing catalysis. (Based on PDB: 1K9O, 1EZX) |
| ᎢᎦ | |
| ᏅᏓᏳᏓᎴᏅᎯ | Own work |
| ᏧᏬᏪᎳᏅᎯ | Thomas Shafee |
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| ᎢᎦ/ᎠᏟᎢᎵᏒ | ᎤᏍᏗ ᏓᏟᎶᏍᏛᎢ | Dimensions | ᎬᏗᏍᎩ | ᏍᏆᎳ ᎪᏪᎵ | |
|---|---|---|---|---|---|
| current | 09:56, 22 ᎥᏍᎩᎦ 2015 | | 1,800 × 1,488 (513 KB) | Evolution and evolvability | Higher resolution |
| 05:19, 19 ᎥᏍᎩᎦ 2015 |  | 1,362 × 1,126 (300 KB) | Evolution and evolvability | Minor arrow correction | |
| 05:08, 19 ᎥᏍᎩᎦ 2015 |  | 1,362 × 1,126 (300 KB) | Evolution and evolvability | added arrow and removed transparency | |
| 05:04, 19 ᎥᏍᎩᎦ 2015 |  | 1,362 × 1,114 (360 KB) | Evolution and evolvability | Cross-wiki upload from en.wikipedia.org |
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